1,1,1,3,3,3-Hexafluoropropan-2-ol (HFIP) is a premium high-purity fluorinated solvent characterized by its exceptional hydrogen bonding donor ability, low nucleophilicity, and high ionizing power. As a clear, colorless, and aromatic oily liquid, HFIP serves as a critical medium in advanced chemical synthesis, allowing complex reactions to proceed under mild conditions that would typically require expensive metal catalysts or aggressive reagents.
Beyond its role as a specialty solvent, HFIP is indispensable in the electronics industry for precision cleaning and as a key building block for high-end fluorinated pharmaceuticals, surfactants, and emulsifiers. Its unique ability to denature proteins while stabilizing α-helical conformations makes it a vital tool in biochemical research, while its compatibility with polymers makes it ideal for developing lithographic and nanopatterning materials.
Detailed Parameters
| Molecular Formula | C3H2F6O | Molecular Weight | 168.04 |
|---|---|---|---|
| CAS RN | 920-66-1 | Physical State | Liquid (20 °C) |
| Boiling Point | 58 °C | Melting Point | -4 °C |
| Specific Gravity | 1.62 (20/20) | Refractive Index | 1.28 |
| Solubility | Soluble in Water, Ether, Acetone | Purity Grade | Available in 99% and 99.5% |
Key Advantages
High Ionizing Power
Facilitates chemical reactions under mild conditions, reducing the need for hazardous additives or expensive catalysts.
Rapid Reaction Rates
Strong H-bonding donor ability accelerates the synthesis of high-end fluorinated intermediates effectively.
Exceptional Solubility
Dissolves amides, ethers, and polymers that are typically insoluble in common organic solvents.
Electronics Grade
Highly effective as a precision cleaning agent and solvent for the semiconductor and electronics industries.
Protein Stabilization
Unique ability to stabilize α-helical conformations, essential for advanced polypeptide research.
Nano-Patterning Use
Ideal for preparing hexafluoroalcohol-functionalized methacrylate polymers for lithography.
Product Gallery
Management Platforms
Quality Assurance
Rigorous purity testing to ensure 99% to 99.5% concentration for high-precision applications.
Process Optimization
Streamlined production of fluorine-containing pharmaceuticals and specialized intermediates.
Safe Logistics
Strict adherence to UN1760 Class 8 Packing Group III standards for safe global transport.
Supply Chain Stability
Consistent availability of raw materials for pesticides and liquid crystal manufacturing.
Storage Control
Recommended cool and dark storage environments to maintain chemical stability and purity.
Technical Support
Expert guidance on applying HFIP in HPLC volatile buffers and polymer synthesis.
Investment Return Comparison
| Performance Metric | Standard Solvents | HFIP Solution |
|---|---|---|
| Reaction Mildness | Requires Catalysts | Self-Catalyzing Properties |
| Polymer Solubility | Limited/Low | High (Amides & Ethers) |
| Processing Time | Standard | Accelerated Synthesis |
| Product Purity | Variable | High Precision (99.5%) |
| Application Range | General Industrial | High-End Specialty Chem |
Frequently Asked Questions
HFIP is widely used in the production of fluorinated pharmaceuticals, surfactants, and emulsifiers, as well as a precision cleaning agent in the electronics industry and a solvent for nanopatterning materials.
It denatures the native state of proteins while simultaneously stabilizing the α-helical conformation of unfolded proteins and polypeptides, making it ideal for structural studies.
It is recommended to store HFIP at room temperature in a cool, dark place to ensure long-term stability and prevent degradation.
Yes, HFIP is used as an acid in volatile buffers for ion pair HPLC, providing specific solvating properties for complex separations.
Its strong hydrogen bonding properties allow it to dissolve substances that are hydrogen-bond acceptors, including various polymers that are insoluble in common organic solvents.
HFIP is classified under UN Number UN1760, Class 8, Packing Group III, requiring specialized hazardous material handling during transport.
